Refractory Leg Ulcers Associated with Klinefelter Syndrome

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Refractory leg ulcers associated with Klinefelter syndrome.

We present a man with refractory leg ulcers, bilateral varicosis of the lower extremities, and Buerger disease. Autoimmune work-up was negative. However, chromosome analysis showed Klinefelter syndrome (48 XXY). Ulcerative lesions of the lower extremities are a complication of Klinefelter syndrome. To date, the pathogenesis of ulcers in Klinefelter syndrome has not been clarified, but several f...

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May-Thurner syndrome: an often overlooked cause for refractory venous leg ulcers.

We report a 53-year-old female patient presenting with a refractory venous leg ulcer and unremarkable findings in the doppler Ultrasound venous mapping of the leg veins. Further comprehensive diagnostics demonstrated an underlying May-Thurner syndrome. After resolution of the primary mechanical obstruction, rapid wound healing in the following 3 weeks was documented. Iliac vein compression synd...

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Leg ulcers associated with Klinefelter's syndrome: a case report and review of the literature.

We present the case of a young man with type II diabetes, stage III chronic kidney disease, hypertension, obstructive sleep apnea and diabetes who presented to the Georgetown University Hospital Center for Wound Healing with refractory lower extremity ulcers. Autoimmune work-up was negative. However, chromosome analysis showed a genetic variant of Klinefelter's syndrome (48 XXYY). Lower extremi...

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ژورنال

عنوان ژورنال: Journal of Nippon Medical School

سال: 2015

ISSN: 1345-4676,1347-3409

DOI: 10.1272/jnms.82.64